The 2021 St. Petersburg Ladies' Trophy is a professional tennis tournament played on indoor hard courts. It is the 12th edition of the tournament and a WTA 500 tournament on the 2021 WTA Tour. The tournament is held between 15 and 21 March 2021.
<sub><sup>1</sup>Qualifiers prize money is also the Round of 32 prize money.</sub><br> <sub>*per team</sub>
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following pair received a wildcard into the doubles main draw:
The following pairs received entry using protected rankings: