The 2021 season is Sport Club Internacional's 111th season in existence. As well as the Campeonato Brasileiro, the club competes in the Copa do Brasil, the Campeonato Gaúcho and the Copa Libertadores.
On March 2, 2021, Internacional announced the hiring of new manager Miguel ÃÂngel RamÃÂrez. After a late finish to the 2020 season due to the COVID-19 pandemic, most first team players did not return to training until March 9 to prepare for the remainder of the Campeonato Gaúcho.
The draw for the round of 16 was held on 1 June 2021.
The league fixtures were announced on 24 March 2021.