The 2021 San Antonio FC season was the club's sixth season of existence. Including the San Antonio Thunder of the original NASL and the former San Antonio Scorpions of the modern NASL, it was the 12th season of professional soccer in San Antonio. The club played in the USL Championship, the second division of the United States soccer league system, and would have participated in the U.S. Open Cup, however the field of teams was reduced due to ongoing COVID-19 pandemic concerns and eventually cancelled.
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