The 2021 Presbyterian Blue Hose football team represented Presbyterian College in the 2021 NCAA Division I FCS football season as a member of the Pioneer Football League (PFL). Led by first-year head coach Kevin Kelley, the Blue Hose played home games at Bailey Memorial Stadium. The team earned national notoriety for never punting.
In the opening game of the season against , Presbyterian quarterback Ren Hefley threw for an FCS single-game record 10 touchdowns in the 84âÂÂ43 win. He completed 38 of 50 pass attempts and threw for 538 yards. Hefley broke the record of nine in a game, which was held by Willie Totten (Mississippi Valley State vs. Kentucky State in 1984) and Drew Hubel (Portland State vs. Weber State in 2007). Blue Hose backup quarterback Tyler Huff added two touchdown passes to set a new Division I team record (for both FCS and FBS) of 12.
Other records broken during this game include: