The 2021 Open de Limoges was a professional tennis tournament played on indoor hard courts. It was the 14th edition of the tournament and part of the 2021 WTA 125 tournaments series, offering a total of $115,000 in prize money. It took place at the Palais des Sports de Beaublanc in Limoges, France, from 13 to 19 December 2021.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw: