The 2021 Nottingham Trophy was a professional tennis tournament played on outdoor grass courts. It was the seventh edition of the tournament which was part of the 2021 ATP Challenger Tour and the 2021 ITF Women's World Tennis Tour. It took place in Nottingham, United Kingdom between 14 and 20 June 2021.
The following players received wildcards into the main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw: