The 2021 Northern Iowa Panthers football team represented the University of Northern Iowa as a member of the Missouri Valley Football Conference (MVFC) during the 2021 NCAA Division I FCS football season. Led by 21st-year head coach Mark Farley, the Panthers compiled an overall record of 6âÂÂ6 with a mark of 4âÂÂ4 in conference play, placing sixth in the MVFC. Northern Iowa received an at-large bid to NCAA Division I Football Championship playoffs, where the Panthers lost to Eastern Washington in the first round. The team played home games at the UNI-Dome in Cedar Falls, Iowa.