The 2021 NCAA Division I baseball season play of college baseball in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began on February 19, 2021. The season progressed through the regular season, many conference tournaments and championship series, and concluded with the 2021 NCAA Division I baseball tournament and 2021 College World Series. The College World Series, consisting of the eight remaining teams in the NCAA tournament and held annually in Omaha, Nebraska, at TD Ameritrade Park Omaha, ended on June 30, 2021. The Mississippi State Bulldogs won the tournament, and were named national champions.
Due to the ongoing COVID-19 pandemic, the start of the season was delayed one week, and some teams opted out of playing at all for the 2021 season. The Ivy League announced on February 18 that no conference competitions would take place, to include conference championships.
The following schools changed conferences effective with the 2022 season:
Of the 32 Division I all-sports athletic conferences, 31 sponsor baseball, with the Big Sky Conference the only exception. All but one of these conferences played in the 2021 season; the Ivy League opted out of the season due to COVID-19 concerns. Several conferences canceled or modified their conference tournaments for 2021, with the Big Ten, Mid-American, Mountain West and West Coast joining the Big West and Pac-12 in forgoing a tournament to end the regular season. For those conferences holding a tournament, the teams in each conference that won their regular season title were given the top seeds in each tournament. The winners of these tournaments received automatic invitations to the 2021 NCAA Division I baseball tournament. Conferences that do not hold a tournament award their automatic bids to the regular-season champion.
This table lists programs that changed head coaches at any point from the first day of the 2021 season until the day before the first day of the 2022 season.