The 2021 Monterrey Open (also known as the Abierto GNP Seguros for sponsorship reasons) was a women's tennis tournament played on outdoor hard courts. It was the 13th edition of the Monterrey Open and a WTA 250 tournament on the 2021 WTA Tour. It took place at the Club Sonoma in Monterrey, Mexico, from 15 to 21 March 2021.
This was Fernandez's first WTA tour title.
<sub>*per team</sub>
The following players received wildcards into the main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
The following pairs received wildcards into the doubles main draw: