The 2021 Major Arena Soccer League season is the thirteenth season for the league. While there are 17 teams in the league, only 11 opted to play for the season due to the COVID-19 pandemic. However, by mid-season, four more opted not to play, which only left the league with 7 teams playing.
All seven teams participated in the playoffs. The regular-season champion received a bye to the semifinals and chose its opponent from among quarterfinal winners. The no. 2 seed chose its opponent for the quarterfinals. The no. 3 seed had second choice of quarterfinal opponents. Each round was a two-game home-and-home series, subject to arena availability, with a 15-minute mini-game following the second game, if necessary.