The 2021 MBC Entertainment Awards () presented by Munhwa Broadcasting Corporation (MBC), took place on December 29, 2021, at MBC Public Hall in Sangam-dong, Mapo-gu, Seoul. It was hosted by Jun Hyun-moo, Lee Sang-yi and Kim Se-jeong, and aired on December 29, 2021, at 20.45 (KST). Yoo Jae-suk won the Grand Prize for Hangout with Yoo for second year in a row.