The 2021 Jordanian Second Division League started on 26 August 2021 and concluded on 29 October 2021.
Al-Hashemiya won the league title and promoted to the 2022 Jordanian First Division League alongside Alia. Adr, Al-Badia, Al-Hamra, and Shabab Al-Hussein were relegated to the Third Division League.
A total of 16 teams contested the league.
The following teams have changed division since the 2019 season.
Relegated from 2021 First Division
Promoted to 2021 First Division
Group 1
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Group 2
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The semi-finals were played between 15 and 22 October 2021.
The final was played on 29 October 2021.