The 2021 Internazionali Femminili di Palermo was a professional women's tennis tournament played on outdoor clay courts at the Country Time Club. It was the 29th edition of the tournament and part of the 2021 WTA Tour. It took place in Palermo, Italy between 19 and 25 July 2021. First-seeded Danielle Collins won the singles title.
Danielle Collins defeated Elena-Gabriela Ruse, 6âÂÂ4, 6âÂÂ2.
The following players received wildcards into the main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
The following pairs received wildcards into the doubles main draw: