The 2021 Internationaux de Strasbourg was a professional tennis tournament played on outdoor clay courts in Strasbourg, France. It was the 35th edition of the tournament and part of the WTA 250 tournaments of the 2021 WTA Tour. It took place at the Tennis Club de Strasbourg between 23 and 29 May 2021.
The following players received wildcard<nowiki>s</nowiki> into the singles main draw:
The following players received entry from the qualifying draw:
The following pairs received wildcards into the doubles main draw:
The following pair received entry using a protected ranking: