The 2021 Indy Pro 2000 Championship was the 23rd season in series history. An 18-round schedule was announced on October 21, 2020, featuring five permanent road courses, two street circuits, and two ovals. The series started on April 17, 2021 at Barber Motorsports Park.
Danish Christian Rasmussen, driving for Jay Howard Driver Development, won the championship in the last race of the season at the Mid-Ohio Sports Car Course.
<nowiki>*</nowiki> The race at Lucas Oil Raceway began on May 28, but was stopped and postponed to May 29 due to inclement weather.
<Nowiki>*</nowiki> Following the cancellation of the Honda Indy Toronto, promoters replaced it with the second Mid-Ohio round.