The 2021 Indiana State Sycamores football team represented Indiana State University as a member of the Missouri Valley Football Conference (MVFC) for the 2021 NCAA Division I FCS football season. Led by fourth-year head coach Curt Mallory, the Sycamores compiled an overall record of 5âÂÂ6 with a mark of 3âÂÂ5 in conference play, tying for seventh place in the MVFC. Indiana State played home games at Memorial Stadium in Terre Haute, Indiana.