The 2021 Houston Cougars football team represented the University of Houston in the 2021 NCAA Division I FBS football season. The Cougars played their home games at TDECU Stadium in Houston, Texas, competing in the American Athletic Conference. They were led by third-year head coach Dana Holgorsen.
The American Athletic Conference preseason media poll was released at the virtual media day held August 4, 2021. Cincinnati, who finished the 2020 season ranked No. 8 nationally, was tabbed as the preseason favorite in the 2021 preseason media poll.