The 2021 Grand Prix de Fourmies was the 88th edition of the Grand Prix de Fourmies, a one-day road cycling race in and around Fourmies in northern France. This edition was the race's first in the UCI ProSeries; the 2020 edition was expected to feature in the inaugural UCI ProSeries but was cancelled due to the COVID-19 pandemic. It was also the ninth event of the 2021 French Road Cycling Cup.
Ten of the nineteen UCI WorldTeams, ten UCI ProTeams, and two UCI Continental teams made up the twenty-two teams that participated in the race. All but four teams fielded a full squad of seven riders; , , , and each entered six riders. In total, 150 riders started the race, of which 134 finished.
UCI WorldTeams
UCI ProTeams
UCI Continental Teams