The 2021 Grampians Trophy was a tournament on the 2021 WTA Tour. It was played on outdoor hardcourts in Melbourne, Australia. It was organised as a lead-up tournament to the 2021 Australian Open, and was held at the same venue, due to other tournaments in Australia being cancelled due to the COVID-19 pandemic. This tournament was created for players who had originally intended to participate in the 2021 Yarra Valley Classic or the 2021 Gippsland Trophy, but were forced to undergo strict quarantine measures upon arrival in Australia due to confirmed COVID-19 cases found on several of the chartered player flights to Australia. There was no doubles event.
Due to a delayed schedule because of a COVID-19 case at a tournament quarantine hotel and the semifinals taking place just one day before the start of the Australian Open, the final was not played.
<sub>*per team</sub>
The following players received entry as an alternate: