The 2021 Grambling State Tigers football team represented Grambling State University in the 2021 NCAA Division I FCS football season. The Tigers were led by eighth-year head coach Broderick Fobbs for the first ten games before he was fired on November 15, with linebackers coach and special teams coordinator Terrence Graves being named interim head coach. They played their home games at Eddie Robinson Stadium in Grambling, Louisiana as members of the West Division of the Southwestern Athletic Conference (SWAC).