The 2021 General Tire 125 was a ARCA Menards Series East race held on May 14, 2021, at the Dover International Speedway in Dover, Delaware. It was contested over 125 laps on the oval. It was the fourth race of the 2021 ARCA Menards Series East season. Joe Gibbs Racing driver Ty Gibbs collected his first win of the East Series season.
Practice and Qualifying were combined for this race. The fastest lap in practice counted as a qualifying lap. Ty Gibbs won the pole with a time of 23.168 seconds and a speed of