The 2021 Drydene 400 was a NASCAR Cup Series race that was held on May 16, 2021, at Dover International Speedway in Dover, Delaware. Contested over 400 laps on the 1-mile (1.6 km) concrete speedway, it was the 13th race of the 2021 NASCAR Cup Series season.
All of Hendrick Motorsports's cars finished in the top four with Alex Bowman taking the checkered flag, the first team to do so since Roush Racing at the 2005 Ford 400.
Martin Truex Jr. was awarded the pole for the race as determined by competition-based formula.
Stage One Laps: 120
Stage Two Laps: 120
Stage Three Laps: 160
Fox Sports covered the race on the television side. Mike Joy, five-time Dover winner Jeff Gordon and Clint Bowyer called the race from the broadcast booth. Jamie Little and Regan Smith handled pit road for the television side. Larry McReynolds provided insight from the Fox Sports studio in Charlotte.
MRN had the radio call for the race and was also simulcasted on Sirius XM NASCAR Radio.