The 2021 Delray Beach Open (officially known as 2021 Delray Beach Open by VITACOST.com for sponsorship reasons) was a professional men's tennis tournament played on hard courts. It was the 29th edition of the tournament, and part of the 2021 ATP Tour. It took place in Delray Beach, Florida, United States between January 7 and January 13, 2021. Due to the COVID-19 pandemic, it was rescheduled from its original dates in mid February. Fourth-seeded Hubert Hurkacz won the singles title.
<sub>*per team</sub>
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following pairs received wildcards into the main draw:
The following pair received entry into the main draw using a protected ranking:
The following pair received entry into the main draw as alternates: