The 2021 Cork Premier Senior Hurling Championship was the second staging of the Cork Premier Senior Hurling Championship and the 133rd staging overall of a championship for the top-ranking hurling teams in Cork. The draw for the group stage placings took place on 29 April 2021. The championship began on 14 July 2021 and ended on 21 November 2021.
Blackrock entered the championship as the defending champions, however, they were beaten by Midleton at the semi-final stage. Carrigtwohill were relegated from the championship after being beaten in a playoff by Charleville.
The final was played on 21 November 2021 at Páirc UàChaoimh in Cork, between Glen Rovers and Midleton, in what was their first meeting in a final in 30 years. Midleton won the match by 0âÂÂ24 to 1âÂÂ18 to claim their eighth championship title overall and a first title since 2013.
Patrick Horgan was the championship's top scorer with 6-56.
Promoted from the Cork Senior A Hurling Championship
Relegated to the Cork Senior A Hurling Championship
The seedings were based on final group stage positions from the 2020 championship.