The 2021 Copa Sudamericana final stages was played from 13 July to 20 November 2021. A total of 16 teams competed in the final stages to decide the champions of the 2021 Copa Sudamericana, with the final played in Montevideo, Uruguay at Estadio Centenario.
The winners of each of the eight groups in the Copa Sudamericana group stage as well as the third-placed teams of each of the eight groups in the Copa Libertadores group stage advanced to the round of 16. <section begin=Qualified teams />
<section begin=Seeding /> Starting from the round of 16, the teams are seeded according to their results in the group stage, with the Copa Sudamericana group winners (Pot 1) seeded 1âÂÂ8, and the Copa Libertadores group third-placed teams (Pot 2) seeded 9âÂÂ16.
<section end=Seeding />
<section begin=Format /> Starting from the round of 16, the teams play a single-elimination tournament with the following rules:
<section begin=Draw /> The draw for the round of 16 was held on 1 June 2021, 12:00 PYT (), at the CONMEBOL Convention Centre in Luque, Paraguay. For the round of 16, the 16 teams were drawn into eight ties (AâÂÂH) between a Copa Sudamericana group winner (Pot 1) and a Copa Libertadores group third-placed (Pot 2), with the Copa Sudamericana group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie (Regulations Article 2.2.3.2).<section end=Draw />
The bracket starting from the round of 16 is determined as follows:
<section begin=Bracket /> The bracket was decided based on the round of 16 draw, which was held on 1 June 2021.
<section end=Bracket />
The first legs were played on 13âÂÂ15 July, and the second legs were played on 20âÂÂ22 July 2021. <section begin=Round of 16 />
<section end=Round of 16 />
Tied 2âÂÂ2 on aggregate, Peñarol won on away goals and advanced to the quarter-finals (Match S1).
Red Bull Bragantino won 3âÂÂ1 on aggregate and advanced to the quarter-finals (Match S2).
Santos won 2âÂÂ1 on aggregate and advanced to the quarter-finals (Match S3).
Athletico Paranaense won 5âÂÂ1 on aggregate and advanced to the quarter-finals (Match S4).
Tied 2âÂÂ2 on aggregate, LDU Quito won on away goals and advanced to the quarter-finals (Match S4).
Tied 4âÂÂ4 on aggregate, Libertad won on away goals and advanced to the quarter-finals (Match S3).
Rosario Central won 3âÂÂ2 on aggregate and advanced to the quarter-finals (Match S2).
Sporting Cristal won 3âÂÂ2 on aggregate and advanced to the quarter-finals (Match S1).
The first legs were played on 10âÂÂ12 August, and the second legs were played on 17âÂÂ19 August 2021. <section begin=Quarter-finals />
<section end=Quarter-finals />
Peñarol won 4âÂÂ1 on aggregate and advanced to the semi-finals (Match F1).
Red Bull Bragantino won 5âÂÂ3 on aggregate and advanced to the semi-finals (Match F2).
Tied 2âÂÂ2 on aggregate, Libertad won on away goals and advanced to the semi-finals (Match F2).
Athletico Paranaense won 4âÂÂ3 on aggregate and advanced to the semi-finals (Match F1).
The first legs were played on 22 and 23 September, and the second legs were played on 29 and 30 September 2021. <section begin=Semi-finals />
<section end=Semi-finals />
Athletico Paranaense won 4âÂÂ1 on aggregate and advanced to the final.
Red Bull Bragantino won 5âÂÂ1 on aggregate and advanced to the final.
The final was played on 20 November 2021 at Estadio Centenario in Montevideo. <section begin=Final /> <section end=Final />