The 2021 Clemson Tigers football team represented Clemson University during the 2021 NCAA Division I FBS football season. The Tigers were led by head coach Dabo Swinney, in his 14th year. The Tigers competed as a member of the Atlantic Coast Conference (ACC) and played their home games at Memorial Stadium in Clemson, South Carolina.
For the first time since 2014, Clemson did not reach the ACC Championship Game or the College Football Playoff. This season ended the team's streak of six consecutive conference championships, the longest in FBS as of the 2021 season.
The Tigers ended the season with a victory over Iowa State in the Cheez-It Bowl.
Clemson's 2021 class consisted of nineteen signees. The class was ranked first in the ACC and fifth best overall by the 247Sports Composite.
<small>Listed in the order that they were released</small>