The 2021 Chicago Women's Open was a tennis tournament held in Chicago, Illinois for female professional tennis players, and part of the 2021 WTA Tour. It was played on outdoor hard courts in the week prior to the 2021 U.S. Open. This marked the first time since 1997 that a WTA tournament was held in Chicago.
This was Svitolina's sixteenth WTA Tour singles title, and first of the year.
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: