The 2021 Cannons Lacrosse Club season was the Cannons Lacrosse Club's 21st season and their first Premier Lacrosse League season.
It was announced that the Cannons would join the PLL as part of the MLLâÂÂPLL merger on December 16, 2020. They held their expansion draft on March 13, 2021.
The Cannons moved from Veterans Memorial Stadium (Quincy, Massachusetts) to Medford when hosting their preseason training. They also rebranded from the "Boston Cannons" to Cannons Lacrosse Club.
The Cannons played their first PLL game in Gillette Stadium on June 4, 2021 in a 12-13 loss to Redwoods Lacrosse Club. They finished the season 3-6, earning a playoff spot.
The Cannons were eliminated from the playoffs in a quarterfinals 13-9 loss to Atlas Lacrosse Club.