2021 Metfone C-League is the 37th season of the C-League. Contested by 13 clubs, it operates on a system of promotion and relegation with Cambodian Second League. Boeung Ket are the defending champions, while Prey Veng makes its debut as the promoted team from the 2020 Cambodian Second League.
The number of foreign players is restricted to five per team. A team can use four foreign players on the field in each game, including at least one player from the AFC region.
Players name in bold indicates the player is registered during the mid-season transfer window.
*Note: Electricite du Cambodge do not use foreign players.
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