The 2021 Mexican Open (also known as the Abierto Mexicano Telcel presentado por HSBC for sponsorship reasons) was a professional tennis tournament played on outdoor hard courts. It was the 28th edition of the men's Mexican Open, and part of the 2021 ATP Tour. It took place in Acapulco, Mexico between 15 and 20 March 2021, at the Princess Mundo Imperial.
The following players received wildcards into the main draw:
The following player received entry using a protected ranking into the singles main draw:
The following player received special exemption into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following pairs received wildcards into the doubles main draw:
The following pair received entry from the qualifying draw:
The following pair received entry as lucky losers: