The 2021 Total 6 Hours of Spa-Francorchamps was an endurance sports car racing event held at the Circuit de Spa-Francorchamps, Stavelot, Belgium on 1 May 2021. It served as the opening round of the 2021 FIA World Endurance Championship, and was the tenth running of the event as part of the championship. The race marked the debut of the new 'Hypercar' era of endurance racing and was won by the debuting #8 Toyota GR010 Hybrid.
Pole position winners in each class are marked in bold.
The minimum number of laps for classification (70% of the overall winning car's race distance) was 113 laps. Class winners are denoted in bold and with .