The 2020 Missouri Secretary of State General election was held on November 3, 2020, to elect the Secretary of State of Missouri. It was held concurrently with the 2020 U.S. presidential election, along with elections to the United States Senate and United States House of Representatives, as well as various state and local elections. Incumbent Republican Secretary of State Jay Ashcroft won re-election to a second term. Ashcroft won with more votes than any candidate in Missouri history.
Ashcroft won six of eight congressional districts.