The 2019 Tre Valli Varesine was the 99th edition of the Tre Valli Varesine road cycling one day race. It was held on 8 October 2019 as part of the 2019 UCI Europe Tour in category 1.HC, over a distance of 197.8 km, starting in Saronno and ending in Varese.
The race was won by Primoà ¾ Rogliàof .
Twenty-two teams were invited to take part in the race. These included fourteen UCI WorldTeams and eight UCI Professional Continental teams.