The 2019 Tallahassee Tennis Challenger was a professional tennis tournament played on green clay courts. It was the 20th edition of the tournament and was part of the 2019 ATP Challenger Tour. It took place in Tallahassee, Florida, United States between April 22 and April 28, 2019.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using their ITF World Tennis Ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: