The 13th edition of the Ronde van Drenthe, a women's cycling race in the Netherlands, was held on 17 March 2019. Italian Marta Bastianelli won the race in a three-way sprint before Dutch riders Chantal Blaak and Ellen van Dijk. The race was held over a distance of , starting and finishing in Hoogeveen. The race covered 11 cobbled sections and three ascents of the VAM-berg. It was the second race of the 2019 UCI Women's World Tour. It was the longest UCI Women's World Tour race ever.
20 UCI teams entered the race, as well as a Dutch national team. Each team has a maximum of six riders: