The 2019 Omloop Het Nieuwsblad was the 14th edition of the Omloop Het Nieuwsblad road cycling one day race, which was held on 2 March. Widely regarded as the start of the Classics season, it was a 1.1 event on the women's international calendar. The race started in Ghent and finished in Ninove.
Twenty-four teams participated in the race. Each team had a maximum of six riders.