The 2019 Lyon Open (also known as the Open Parc Auvergne-Rhône-Alpes Lyon) was a men's tennis tournament played on outdoor clay courts. It was the third edition of the Lyon Open and part of the ATP Tour 250 series of the 2019 ATP Tour. It took place in the city of Lyon, France, from 19 May through 25 May 2019. Unseeded Benoît Paire won the singles title.
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
The following pairs received wildcards into the doubles main draw:
The following pairs received entry as alternates: