The 2019 Gainesville, Florida mayoral election took place on March 19, 2019. Incumbent Mayor Lauren Poe ran for re-election to a second term. He was challenged by three candidates: community activist Jenn Powell, legal assistant Jennifer Reid, and community college student Marlon Bruce. Poe won re-election in a landslide, winning 62 percent of the vote.
Following an amendment to the city charter, this was the last election to take place in an odd-numbered year and the last election for a three-year term.