The 2019 Copa Sudamericana second stage was played from 21 to 30 May 2019. A total of 32 teams competed in the second stage to decide the 16 places in the final stages of the 2019 Copa Sudamericana.
<section begin=Draw /> The draw for the second stage was held on 13 May 2019, 20:30 PYT (), at the CONMEBOL Convention Centre in Luque, Paraguay. For the second stage, the teams were allocated to two pots according to their previous results in this season:
The 32 teams were drawn into 16 ties (O1âÂÂO16) between a team from Pot 1 and a team from Pot 2, with the teams from Pot 1 hosting the second leg. Teams from the same association could be drawn into the same tie.<section end=Draw />
The following were the 10 teams transferred from the Copa Libertadores (two best teams eliminated in the third stage of qualifying and eight third-placed teams in the group stage). <section begin=Qualified teams /> <section end=Qualified teams />
The following were the 22 winners of the first stage from the Copa Sudamericana. Matches in the first stage were considered for the ranking of teams for the second stage draw. <section begin=Qualified teams /> <section end=Qualified teams />
<section begin=Format /> In the second stage, each tie was played on a home-and-away two-legged basis. If tied on aggregate, the away goals rule was used. If still tied, extra time was not played, and a penalty shoot-out was used to determine the winner (Regulations Article 27).
The 16 winners of the second stage advanced to the round of 16 of the final stages.<section end=Format />
The first legs were played on 21âÂÂ23 May, and the second legs were played on 28âÂÂ30 May 2019. <section begin=Second stage />
<section end=Second stage />
La Equidad won 4âÂÂ1 on aggregate and advanced to the round of 16 (Match A).
Independiente del Valle won 7âÂÂ3 on aggregate and advanced to the round of 16 (Match B).
Fluminense won 4âÂÂ2 on aggregate and advanced to the round of 16 (Match C).
Sporting Cristal won 6âÂÂ0 on aggregate and advanced to the round of 16 (Match D).
Argentinos Juniors won 1âÂÂ0 on aggregate and advanced to the round of 16 (Match E).
Montevideo Wanderers won 1âÂÂ0 on aggregate and advanced to the round of 16 (Match F).
Universidad Católica won 6âÂÂ0 on aggregate and advanced to the round of 16 (Match G).
Tied 1âÂÂ1 on aggregate, Atlético Mineiro won on penalties and advanced to the round of 16 (Match H).
Botafogo won 5âÂÂ0 on aggregate and advanced to the round of 16 (Match H).
Independiente won 4âÂÂ3 on aggregate and advanced to the round of 16 (Match G).
Corinthians won 4âÂÂ0 on aggregate and advanced to the round of 16 (Match F).
Colón won 3âÂÂ1 on aggregate and advanced to the round of 16 (Match E).
Zulia won 3âÂÂ1 on aggregate and advanced to the round of 16 (Match D).
Peñarol won 3âÂÂ1 on aggregate and advanced to the round of 16 (Match C).
Caracas won 2âÂÂ1 on aggregate and advanced to the round of 16 (Match B).
Tied 3âÂÂ3 on aggregate, Royal Pari won on away goals and advanced to the round of 16 (Match A).