The 2018 Lyon Open (also known as the Open Parc Auvergne-Rhône-Alpes Lyon) was a men's tennis tournament played on outdoor clay courts. It was the second edition of the Lyon Open and part of the ATP World Tour 250 series of the 2018 ATP World Tour. It took place in the city of Lyon, France, from May 20 through May 26, 2018.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
The following pairs received wildcards into the doubles main draw: