The 2016 South Florida Bulls football team represented the University of South Florida (USF) in the 2016 NCAA Division I FBS football season. The 2016 season is the 20th season for the Bulls, and their fourth as a member of the American Athletic Conference (The American). They played their home games at Raymond James Stadium in Tampa, Florida, and were led during the regular season by head coach Willie Taggart, who was in his fourth year. Following the regular season, but before the team's appearance in the Birmingham Bowl, Taggart left to take the head coaching vacancy at Oregon, with co-offensive coordinator T. J. Weist named as interim head coach for the bowl game.
This was the first time in program history that the Bulls finished a season ranked in the AP Poll.