The 2016 S.League (also known as the Great Eastern Yeo's S.League for sponsorship reasons) was the 21st season of the S.League, the top-flight Singaporean professional league for association football clubs, since its establishment in 1996. The season began on 13 February 2016, and concluded on 28 October 2016. DPMM FC were the defending champions.
A total of 9 teams competed in the league. Albirex Niigata (S) and DPMM FC were invited foreign clubs from Japan and Brunei respectively.
<small>Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.</small>
Players name in bold indicates the player is registered during the mid-season transfer window.
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Mid-week
<sup>4</sup> Player scored 4 goals