The 2016 Presbyterian Blue Hose football team represented Presbyterian College in the 2016 NCAA Division I FCS football season. They were led by eighth-year head coach Harold Nichols and played their home games at Bailey Memorial Stadium. They were a member of the Big South Conference. They finished the season 2âÂÂ9, 1âÂÂ4 in Big South play to finish in fifth place.
On December 20, head coach Harold Nichols resigned. He finished at Presbyterian with an eight year record of 21âÂÂ67.