The 2016 Open Harmonie mutuelle was a professional tennis tournament played on hard courts. It was the thirteenth edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Saint-Brieuc, France between 28 March and 3 April 2016.
The following players received wildcards into the singles main draw:
The following players received entry as an alternate:
The following players received entry from the qualifying draw: