The 2016 Cadel Evans Great Ocean Road Race was a road cycling one-day classic that took place on 31 January 2016 in Victoria, Australia. The race, which covered a distance of , started and finished in Geelong, where it used a circuit similar to that used in the 2010 world championships road race. It was the second edition of the Cadel Evans Great Ocean Road Race.
The race was won in a solo attack by Peter Kennaugh (). He attacked from a small group on the final climb and held off the chasers for the to the finish line. He finished six seconds ahead of a group of 19 riders: the sprint for second was won by Leigh Howard () with Niccolò Bonifazio () third.