The 2016 Argentina Open was a men's tennis tournament played on outdoor clay courts. It was the 19th edition of the ATP Buenos Aires event, and part of the ATP World Tour 250 series of the 2016 ATP World Tour. It took place in Buenos Aires, Argentina, from 8 February through 14 February 2016. Fifth-seeded Dominic Thiem won the singles title.
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following pairs received wildcards into the main draw: