2015 Tampa Bay Rays season

|- bgcolor="ffbbbb" | 1 || April 6 || Orioles || 2–6 || Tillman (1–0) || Archer (0–1) || — || 31,042 || 0–1 || https://www.baseball-reference.com/boxes/TBA/TBA201504060.shtml |- bgcolor="ffbbbb" | 2 || April 7 || Orioles || 5–6 || Gausman (1–0) || Karns (0–1) || Britton (1) || 13,906 || 0–2 || https://www.baseball-reference.com/boxes/TBA/TBA201504070.shtml |- bgcolor="bbffbb" | 3 || April 8 || Orioles || 2–0 || Odorizzi (1–0) || González (0–1) || Boxberger (1) || 13,569 || 1–2 || https://www.baseball-reference.com/boxes/TBA/TBA201504080.shtml |- bgcolor="ffbbbb" | 4 || April 10 || @ Marlins || 9–10 <small>(10)</small> || Morris (1–0) || Boxberger (0–1) || — || 17,375 || 1–3 || https://www.baseball-reference.com/boxes/MIA/MIA201504100.shtml |- bgcolor="bbffbb" | 5 || April 11 || @ Marlins || 2–0 || Archer (1–1) || Cosart (0–1) || Boxberger (2) || 17,830 || 2–3 || https://www.baseball-reference.com/boxes/MIA/MIA201504110.shtml |- bgcolor="bbffbb" | 6 || April 12 || @ Marlins || 8–5 || Karns (1–1) || Álvarez (0–2) || Frieri (1) || 20,199 || 3–3 || https://www.baseball-reference.com/boxes/MIA/MIA201504120.shtml |- bgcolor="bbffbb" | 7 || April 13 || @ Blue Jays || 2–1 || Odorizzi (2–0) || Dickey (0–1) || Boxberger (3) || 48,414 || 4–3 || https://www.baseball-reference.com/boxes/TOR/TOR201504130.shtml |- bgcolor="bbffbb" | 8 || April 14 || @ Blue Jays || 3–2 || Geltz (1–0) || Castro (0–1) || Jepsen (1) || 17,264 || 5–3 || https://www.baseball-reference.com/boxes/TOR/TOR201504140.shtml |- bgcolor="ffbbbb" | 9 || April 15 || @ Blue Jays || 7–12 || Buehrle (2–0) || Ramírez (0–1) || — || 15,086 || 5–4 || https://www.baseball-reference.com/boxes/TOR/TOR201504150.shtml |- bgcolor="bbffbb" | 10 || April 16 || @ Blue Jays || 4–2 || Archer (2–1) || Sanchez (0–2) || Boxberger (4) || 14,433 || 6–4 || https://www.baseball-reference.com/boxes/TOR/TOR201504160.shtml |- bgcolor="ffbbbb" | 11 || April 17 || Yankees || 4–5 || Betances (2–0) || Jepsen (0–1) || Miller (3) || 15,572 || 6–5 || https://www.baseball-reference.com/boxes/TBA/TBA201504170.shtml |- bgcolor="ffbbbb" | 12 || April 18 || Yankees || 0–9 || Tanaka (2–1) || Odorizzi (2–1) || — || 20,824 || 6–6 || https://www.baseball-reference.com/boxes/TBA/TBA201504180.shtml |- bgcolor="ffbbbb" | 13 || April 19 || Yankees || 3–5 || Pineda (2–0) || Andriese (0–1) || Miller (4) || 21,791 || 6–7 || https://www.baseball-reference.com/boxes/TBA/TBA201504190.shtml |- bgcolor="ffbbbb" | 14 || April 21 || Red Sox || 0–1 || Miley (1–1) || Archer (2–2) || Uehara (2) || 14,307 || 6–8 || https://www.baseball-reference.com/boxes/TBA/TBA201504210.shtml |- bgcolor="bbffbb" | 15 || April 22 || Red Sox || 7–5 || Boxberger (1–1) || Mujica (1–1) || Geltz (1) || 12,733 || 7–8 || https://www.baseball-reference.com/boxes/TBA/TBA201504220.shtml |- bgcolor="bbffbb" | 16 || April 23 || Red Sox || 2–1 || Boxberger (2–1) || Varvaro (0–1) || — || 13,834 || 8–8 || https://www.baseball-reference.com/boxes/TBA/TBA201504230.shtml |- bgcolor="bbffbb" | 17 || April 24 || Blue Jays || 12–3 || Dominguez (1–0) || Dickey (0–2) || Andriese (1) || 11,897 || 9–8 || https://www.baseball-reference.com/boxes/TBA/TBA201504240.shtml |- bgcolor="bbffbb" | 18 || April 25 || Blue Jays || 4–2 || Frieri (1–0) || Cecil (1–2) || Boxberger (5) || 19,772 || 10–8 || https://www.baseball-reference.com/boxes/TBA/TBA201504250.shtml |- bgcolor="bbffbb" | 19 || April 26 || Blue Jays || 5–1 || Archer (3–2) || Buehrle (3–1) || — || 21,107 || 11–8 || https://www.baseball-reference.com/boxes/TBA/TBA201504260.shtml |- bgcolor="ffbbbb" | 20 || April 27 || @ Yankees || 1–4 || Wilson (1–0) || Gomes (0–1) || Miller (8) || 34,590 || 11–9 || https://www.baseball-reference.com/boxes/NYA/NYA201504270.shtml |- bgcolor="ffbbbb" | 21 || April 28 || @ Yankees || 2–4 || Whitley (1–0) || Odorizzi (2–2) || Martin (1) || 36,934 || 11–10 || https://www.baseball-reference.com/boxes/NYA/NYA201504280.shtml |- bgcolor="bbffbb" | 22 || April 29 || @ Yankees || 3–2 <small>(13)</small> || Gomes (1–1) || Shreve (1–1) || Frieri (2) || 30,055 || 12–10 || https://www.baseball-reference.com/boxes/NYA/NYA201504290.shtml |-

|- bgcolor="bbffbb" | 23 || May 1 || @ Orioles || 2–0 || Colomé (1–0) || Tillman (2–3) || Boxberger (6) || 9,945 || 13–10 || https://www.baseball-reference.com/boxes/TBA/TBA201505010.shtml |- bgcolor="ffbbbb" | 24 || May 2 || @ Orioles || 0–4 || González (3–1) || Archer (3–3) || Brach (1) || 12,789 || 13–11 || https://www.baseball-reference.com/boxes/TBA/TBA201505020.shtml |- bgcolor="ffbbbb" | 25 || May 3 || @ Orioles || 2–4 || Hunter (1–1) || Geltz (1–1) || Britton (5) || 16,652 || 13–12 || https://www.baseball-reference.com/boxes/TBA/TBA201505030.shtml |- bgcolor="bbffbb" | 26 || May 4 || @ Red Sox || 5–1 || Odorizzi (3–2) || Buchholz (1–4) || — || 34,541 || 14–12 || https://www.baseball-reference.com/boxes/BOS/BOS201505040.shtml |- bgcolor="ffbbbb" | 27 || May 5 || @ Red Sox || 0–2 || Porcello (3–2) || Smyly (0–1) || Uehara (5) || 33,688 || 14–13 || https://www.baseball-reference.com/boxes/BOS/BOS201505050.shtml |- bgcolor="bbffbb" | 28 || May 6 || @ Red Sox || 5–3 || Colomé (2–0) || Masterson (2–1) || Boxberger (7) || 35,060 || 15–13 || https://mlb.com/gameday/414066 |- bgcolor="ffcccc" | 29 || May 7 || Rangers || 4–5 || Claudio (1–0) || Archer (3–4) || Feliz (4) || 8,701 || 15–14 || https://www.baseball-reference.com/boxes/TBA/TBA201505070.shtml |- bgcolor="ccffcc" | 30 || May 8 || Rangers || 8–2 || Karns (2–1) || Gallardo (2–5) || — || 11,704 || 16–14 || https://www.baseball-reference.com/boxes/TBA/TBA201505080.shtml |- bgcolor="ccffcc" | 31 || May 9 || Rangers || 7–2 || Bellatti (1–0) || Detwiler (0–4) || Boxberger (8) || 20,943 || 17–14 || https://www.baseball-reference.com/boxes/TBA/TBA201505090.shtml |- bgcolor="ffcccc" | 32 || May 10 || Rangers || 1–2 || Kela (3–1) || Jepsen (0–2) || Feliz (5) || 14,521 || 17–15 || https://www.baseball-reference.com/boxes/TBA/TBA201505100.shtml |- bgcolor="ffcccc" | 33 || May 11 || Yankees || 5–11 || Sabathia (1–5) || Colomé (2–1) || — || 10,619 || 17–16 || https://www.baseball-reference.com/boxes/TBA/TBA201505110.shtml |- bgcolor="ccffcc" | 34 || May 12 || Yankees || 4–2 || Jepsen (1–2) || Eovaldi (3–1) || Boxberger (9) || 10,417 || 18–16 || https://www.baseball-reference.com/boxes/TBA/TBA201505120.shtml |- bgcolor="ccffcc" | 35 || May 13 || Yankees || 3–2 || Karns (3–1) || Warren (2–2) || Boxberger (10) || 11,924 || 18–16 || https://www.baseball-reference.com/boxes/TBA/TBA201505130.shtml |- bgcolor="ccffcc" | 36 || May 14 || Yankees || 6–1 || Ramírez (1–1) || Whitley (1–2) || Andriese (2) || 11,977 || 19–16 || https://www.baseball-reference.com/boxes/TBA/TBA201505140.shtml |- bgcolor="ffcccc" | 37 || May 15 || @ Twins || 2–3 || Hughes (3–4) || Odorizzi (3–3) || Perkins (12) || 24,018 || 20–17 || https://www.baseball-reference.com/boxes/MIN/MIN201505150.shtml |- bgcolor="ffcccc" | 38 || May 16 || @ Twins || 4–6 || Duensing (1–0) || Jepsen (1–3) || Perkins (13) || 27,128 || 20–18 || https://www.baseball-reference.com/boxes/MIN/MIN201505160.shtml |- bgcolor="ccffcc" | 39 || May 17 || @ Twins || 11–3 || Archer (4–4) || Gibson (3–3) || — || 23,708 || 21–18 || https://www.baseball-reference.com/boxes/MIN/MIN201505160.shtml |- bgcolor="ccffcc" | 40 || May 19 || @ Braves || 5–3 || Ramírez (2–1) || Foltynewicz (2–1) || Boxberger (11) || 20,120 || 22–18 || https://www.baseball-reference.com/boxes/ATL/ATL201505190.shtml |- bgcolor="ffcccc" | 41 || May 20 || @ Braves || 1–2 || Cunniff (2–0) || Odorizzi (3–4) || Grilli (12) || 24,549 || 22–19 || https://www.baseball-reference.com/boxes/ATL/ATL201505200.shtml |- bgcolor="ccffcc" | 42 || May 21 || Athletics || 3–0 || Colomé (3–1) || Chavez (1–4) || Boxberger (12) || 10,605 || 23–19 || https://www.baseball-reference.com/boxes/TBA/TBA201505210.shtml |- bgcolor="ccffcc" | 43 || May 22 || Athletics || 5–2 || Archer (5–4) || Kazmir (2–3) || Boxberger (13) || 12,329 || 24–19 || https://www.baseball-reference.com/boxes/TBA/TBA201505220.shtml |- bgcolor="ffcccc" | 44 || May 23 || Athletics || 0–5 || Graveman (2–2) || Karns (3–2) || — || 15,207 || 24–20 || https://www.baseball-reference.com/boxes/TBA/TBA201505230.shtml |- bgcolor="ffcccc" | 45 || May 24 || Athletics || 2–7 || Gray (5–2) || Ramírez (2–2) || — || 15,692 || 24–21 || https://www.baseball-reference.com/boxes/TBA/TBA201505240.shtml |- bgcolor="ffcccc" | 46 || May 25 || Mariners || 1–4 || Elías (2–1) || Odorizzi (3–5) || Rodney (13) || 10,401 || 24–22 || https://www.baseball-reference.com/boxes/TBA/TBA201505250.shtml |- bgcolor="ffcccc" | 47 || May 26 || Mariners || 6–7 || Rodney (2–2) || Boxberger (2–2) || Beimel (1) || 9,628 || 24–23 || https://www.baseball-reference.com/boxes/TBA/TBA201505260.shtml |- bgcolor="ffcccc" | 48 || May 27 || Mariners || 0–3 || Hernández (8–1) || Boxberger (2–3) || — || 10,365 || 24–24 || https://www.baseball-reference.com/boxes/TBA/TBA201505270.shtml |- bgcolor="ffcccc" | 49 || May 29 || @ Orioles || 1–2 || O'Day (1–0) || Gomes (1–2) || — || 45,505 || 24–25 || https://www.baseball-reference.com/boxes/BAL/BAL201505290.shtml |- bgcolor="ccffcc" | 50 || May 30 || @ Orioles || 3–0 || Ramírez (3–2) || Chen (1–4) || Boxberger (14) || 38,177 || 25–25 || https://www.baseball-reference.com/boxes/BAL/BAL201505300.shtml |- bgcolor="ccffcc" | 51 || May 31 || @ Orioles || 9–5 || Odorizzi (4–5) || Tillman (2–7) || Boxberger (15) || 36,945 || 26–25 || https://www.baseball-reference.com/boxes/BAL/BAL201505310.shtml |-

|- bgcolor="ffcccc" | 52 || June 1 || @ Angels || 3–7 || Richards (5–3) || Colomé (3–2) || — || 27,078 || 26–26 || https://www.baseball-reference.com/boxes/ANA/ANA201506010.shtml |- bgcolor="ccffcc" | 53 || June 2 || @ Angels || 6–1 || Archer (6–4) || Wilson (3–4) || — || 28,771 || 27–26 || https://www.baseball-reference.com/boxes/ANA/ANA201506020.shtml |- bgcolor="ccffcc" | 54 || June 3 || @ Angels || 6–5 <small>(10)</small> || Boxberger (3–3) || Street (2–2) || Geltz (2) || 28,245 || 28–26 || https://www.baseball-reference.com/boxes/ANA/ANA201506030.shtml |- bgcolor="ccffcc" | 55 || June 4 || @ Mariners || 2–1 || Ramírez (4–2) || Elías (2–3) || Jepsen (2) || 16,096 || 29–26 || https://www.baseball-reference.com/boxes/SEA/SEA201506040.shtml |- bgcolor="ccffcc" | 56 || June 5 || @ Mariners || 1–0 || Bellatti (2–0) || Rodney (2–3) || Jepsen (3) || 20,695 || 30–26 || https://www.baseball-reference.com/boxes/SEA/SEA201506050.shtml |- bgcolor="ffcccc" | 57 || June 6 || @ Mariners || 1–2 || Hernández (9–2) || Geltz (1–2) || Smith (1) || 31,106 || 30–27 || https://www.baseball-reference.com/boxes/SEA/SEA201506060.shtml |- bgcolor="ccffcc" | 58 || June 7 || @ Mariners || 3–1 || Archer (7–4) || Montgomery (0–1) || Jepsen (4) || 27,906 || 31–27 || https://www.baseball-reference.com/boxes/SEA/SEA201506070.shtml |- bgcolor="ffcccc" | 59 || June 9 || Angels || 2–8 || Shoemaker (4–4) || Karns (3–3) || — || 11,617 || 31–28 || https://www.baseball-reference.com/boxes/TBA/TBA201506090.shtml |- bgcolor="ccffcc" | 60 || June 10 || Angels || 4–2 || Ramírez (5–2) || Weaver (4–6) || McGee (1) || 10,088 || 32–28 || https://www.baseball-reference.com/boxes/TBA/TBA201506100.shtml |- bgcolor="ffcccc" | 61 || June 11 || Angels || 2–6 || Richards (6–4) || Jepsen (1–4) || — || 10,779 || 32–29 || https://www.baseball-reference.com/boxes/TBA/TBA201506110.shtml |- bgcolor="ccffcc" | 62 || June 12 || White Sox || 7–5 || Andriese (1–1) || Danks (3–3) || McGee (2) || 13,448 || 33–29 || https://www.baseball-reference.com/boxes/TBA/TBA201506120.shtml |- bgcolor="ccffcc" | 63 || June 13 || White Sox || 5–4 || Boxberger (4–3) || Putnam (1–2) || McGee (3) || 20,248 || 34–29 || https://www.baseball-reference.com/boxes/TBA/TBA201506130.shtml |- bgcolor="ccffcc" | 64 || June 14 || White Sox || 2–1 || Riefenhauser (1–0) || Sale (6–3) || Jepsen (5) || 17,962 || 35–29 || https://www.baseball-reference.com/boxes/TBA/TBA201506140.shtml |- bgcolor="ccffcc" | 65 || June 15 || Nationals || 6–1 || Ramírez (6–2) || González (4–4) || — || 10,216 || 36–29 || https://www.baseball-reference.com/boxes/TBA/TBA201506150.shtml |- bgcolor="ffcccc" | 66 || June 16 || Nationals || 4–16 || Roark (3–2) || Colomé (3–3) || — || 11,491 || 36–30 || https://www.baseball-reference.com/boxes/TBA/TBA201506160.shtml |- bgcolor="ccffcc" | 67 || June 17 || @ Nationals || 5–0 || Andriese (2–1) || Zimmerman (5–5) || — || 28,929 || 37–30 || https://www.baseball-reference.com/boxes/WAS/WAS201506170.shtml |- bgcolor="ccffcc" | 68 || June 18 || @ Nationals || 5–3 || Archer (8–4) || Fister (2–3) || Boxberger (16) || 29,242 || 38–30 || https://www.baseball-reference.com/boxes/WAS/WAS201506180.shtml |- bgcolor="ccffcc" | 69 || June 19 || @ Indians || 4–1 || Karns (4–3) || Carrasco (8–6) || Boxberger (17) || 22,811 || 39–30 || https://www.baseball-reference.com/boxes/CLE/CLE201506190.shtml |- bgcolor="ccffcc" | 70 || June 20 || @ Indians || 4–1 || Cedeño (1–0) || Kluber (3–9) || Boxberger (18) || 24,670 || 40–30 || https://www.baseball-reference.com/boxes/CLE/CLE201506200.shtml |- bgcolor="ffcccc" | 71 || June 21 || @ Indians || 0–1 || Allen (1–2) || Jepsen (1–5) || — || 20,847 || 40–31 || https://www.baseball-reference.com/boxes/CLE/CLE201506210.shtml |- bgcolor="ffcccc" | 72 || June 22 || Blue Jays || 5–8 || Hutchison (7–1) || Andriese (2–2) || Osuna (1) || 10,324 || 40–32 || https://www.baseball-reference.com/boxes/TBA/TBA201506220.shtml |- bgcolor="ccffcc" | 73 || June 23 || Blue Jays || 4–3 || Archer (9–4) || Dickey (3–7) || Boxberger (19) || 11,474 || 41–32 || https://www.baseball-reference.com/boxes/TBA/TBA201506230.shtml |- bgcolor="ffcccc" | 74 || June 24 || Blue Jays || 0–1 <small>(12)</small> || Cecil (2–4) || Gomes (1–3) || Delabar (1) || 18,469 || 41–33 || https://www.baseball-reference.com/boxes/TBA/TBA201506240.shtml |- bgcolor="ffcccc" | 75 || June 26 || Red Sox || 3–4 <small>(10)</small> || Ogando (2–0) || Geltz (1–3) || Uehara (15) || 17,508 || 41–34 || https://www.baseball-reference.com/boxes/TBA/TBA201506260.shtml |- bgcolor="ccffcc" | 76 || June 27 || Red Sox || 4–1 || Andriese (3–2) || Miley (7–7) || Boxberger (20) || 23,876 || 42–34 || https://www.baseball-reference.com/boxes/TBA/TBA201506270.shtml |- bgcolor="ffcccc" | 77 || June 28 || Red Sox || 3–5 || Masterson (3–2) || Archer (9–5) || Uehara (16) || 21,963 || 42–35 || https://www.baseball-reference.com/boxes/TBA/TBA201506280.shtml |- bgcolor="ffcccc" | 78 || June 29 || Indians || 1–7 || Anderson (1–0) || Karns (4–4) || — || 11,802 || 42–36 || https://www.baseball-reference.com/boxes/TBA/TBA201506290.shtml |- bgcolor="ffcccc" | 79 || June 30 || Indians || 2–6 || Salazar (7–3) || Ramírez (6–3) || — || 10,437 || 42–37 || https://www.baseball-reference.com/boxes/TBA/TBA201506300.shtml |-

|- bgcolor="ffcccc" | 105 || August 1 || @ Red Sox || 7–11 || Kelly (3–6) || Moore (1–3) || Machi (1) || 35,944 || 51–54 || https://www.baseball-reference.com/boxes/BOS/BOS201508010.shtml |- bgcolor="ccffcc" | 106 || August 2 || @ Red Sox || 4–3 || Geltz (2–4) || Tazawa (2–4) || Boxberger (26) || 35,699 || 52–54 || https://www.baseball-reference.com/boxes/BOS/BOS201508020.shtml |- bgcolor="ccffcc" | 107 || August 3 || @ White Sox || 5–4 || McGee (1–1) || Robertson (4–3) || Boxberger (27) || 16,496 || 53–54 || https://www.baseball-reference.com/boxes/CHA/CHA201508030.shtml |- bgcolor="ccffcc" | 108 || August 4 || @ White Sox || 11–3 || Archer (10–8) || Sale (9–7) || — || 18,499 || 54–54 || https://www.baseball-reference.com/boxes/CHA/CHA201508040.shtml |- bgcolor="ffcccc" | 109 || August 5 || @ White Sox || 5–6 <small>(10)</small> || Robertson (5–3) || Boxberger (4–7) || — || 20,028 || 54–55 || https://www.baseball-reference.com/boxes/CHA/CHA201508050.shtml |- bgcolor="ffcccc" | 110 || August 7 || Mets || 3–4 || Clippard (2–3) || Boxberger (4–8) || Familia (30) || 23,145 || 54–56 || https://www.baseball-reference.com/boxes/TBA/TBA201508070.shtml |- bgcolor="ccffcc" | 111 || August 8 || Mets || 5–4 || Karns (7–5) || Syndergaard (6–6) || Boxberger (28) || 31,042 || 55–56 || https://www.baseball-reference.com/boxes/TBA/TBA201508080.shtml |- bgcolor="ccffcc" | 112 || August 9 || Mets || 4–3 || Cedeño (2–1) || Colón (10–11) || McGee (6) || 26,681 || 56–56 || https://www.baseball-reference.com/boxes/TBA/TBA201508090.shtml |- bgcolor="ccffcc" | 113 || August 11 || Braves || 2–0 || Ramírez (9–4) || Pérez (4–3) || Cedeño (1) || 15,506 || 57–56 || https://www.baseball-reference.com/boxes/TBA/TBA201508110.shtml |- bgcolor="ccffcc" | 114 || August 12 || Braves || 9–6 || Colomé (5–4) || Marksberry (0–1) || Boxberger (29) || 16,337 || 58–56 || https://www.baseball-reference.com/boxes/TBA/TBA201508120.shtml |- bgcolor="ffcccc" | 115 || August 14 || @ Rangers || 3–5 || Dyson (4–4) || McGee (1–2) || Tolleson (22) || 32,512 || 58–57 || https://www.baseball-reference.com/boxes/TEX/TEX201508140.shtml |- bgcolor="ffcccc" | 116 || August 15 || @ Rangers || 4–12 || Lewis (13–5) || Archer (10–9) || — || 32,351 || 58–58 || https://www.baseball-reference.com/boxes/TEX/TEX201508150.shtml |- bgcolor="ffcccc" | 117 || August 16 || @ Rangers || 3–5 || Gallardo (9–9) || Smyly (0–2) || Tolleson (23) || 29,167 || 58–59 || https://www.baseball-reference.com/boxes/TEX/TEX201508160.shtml |- bgcolor="ccffcc" | 118 || August 17 || @ Astros || 9–2 || Ramírez (10–4) || Kazmir (6–8) || — || 16,256 || 59–59 || https://www.baseball-reference.com/boxes/HOU/HOU201508170.shtml |- bgcolor="ffcccc" | 119 || August 18 || @ Astros || 2–3 <small>(10)</small> || Gregerson (6–2) || Boxberger (4–9) || — || 17,749 || 59–60 || https://www.baseball-reference.com/boxes/HOU/HOU201508180.shtml |- bgcolor="ffcccc" | 120 || August 19 || @ Astros || 2–3 <small>(13)</small> || Fields (4–1) || Andriese (3–3) || — || 26,001 || 59–61 || https://www.baseball-reference.com/boxes/HOU/HOU201508190.shtml |- bgcolor="ccffcc" | 121 || August 20 || @ Astros || 1–0 || Archer (11–9) || McHugh (13–7) || — || 18,177 || 60–61 || https://www.baseball-reference.com/boxes/HOU/HOU201508200.shtml |- bgcolor="ccffcc" | 122 || August 21 || @ Athletics || 2–1 || Smyly (1–2) || Bassitt (1–5) || Boxberger (30) || 20,671 || 61–61 || https://www.baseball-reference.com/boxes/OAK/OAK201508210.shtml |- bgcolor="ccffcc" | 123 || August 22 || @ Athletics || 5–4 || Colomé (6–4) || Venditte (0–2) || — || 35,067 || 62–61 || https://www.baseball-reference.com/boxes/OAK/OAK201508220.shtml |- bgcolor="ffcccc" | 124 || August 23 || @ Athletics || 2–8 || Rodriguez (3–1) || Geltz (2–5) || — || 19,425 || 62–62 || https://www.baseball-reference.com/boxes/OAK/OAK201508230.shtml |- bgcolor="ffcccc" | 125 || August 25 || Twins || 7–11 || Graham (1–1) || Andriese (3–4) || — || 9,632 || 62–63 || https://www.baseball-reference.com/boxes/TBA/TBA201508250.shtml |- bgcolor="ffcccc" | 126 || August 26 || Twins || 3–5 || Duensing (4–0) || Archer (11–10) || Jepsen (8) || 9,205 || 62–64 || https://www.baseball-reference.com/boxes/TBA/TBA201508260.shtml |- bgcolor="ccffcc" | 127 || August 27 || Twins || 5–4 || Gomes (2–4) || Milone (6–4) || Boxberger (31) || 9,375 || 63–64 || https://www.baseball-reference.com/boxes/TBA/TBA201508270.shtml |- bgcolor="ffcccc" | 128 || August 28 || Royals || 2–3 || Vólquez (12–7) || Ramírez (10–5) || Holland (29) || 13,622 || 63–65 || https://www.baseball-reference.com/boxes/TBA/TBA201508280.shtml |- bgcolor="ffcccc" | 129 || August 29 || Royals || 3–6 || Medlen (3–0) || Odorizzi (6–7) || Davis (13) || 24,372 || 63–66 || https://www.baseball-reference.com/boxes/TBA/TBA201508290.shtml |- bgcolor="ccffcc" | 130 || August 30 || Royals || 3–2 || Cedeño (3–1) || Hochevar (1–1) || Boxberger (32) || 18,634 || 64–66 || https://www.baseball-reference.com/boxes/TBA/TBA201508300.shtml |- bgcolor="ccffcc" | 131 || August 31 || @ Orioles || 6–3 || Archer (12–10) || Chen (8–7) || Boxberger (33) || 19,841 || 65–66 || https://www.baseball-reference.com/boxes/BAL/BAL201508310.shtml |-

|- bgcolor="ccffcc" | 132 || September 1 || @ Orioles || 11–2 || Smyly (2–2) || Tillman (9–10) || — || 22,987 || 66–66 || https://www.baseball-reference.com/boxes/BAL/BAL201509010.shtml |- bgcolor="ffcccc" | 133 || September 2 || @ Orioles || 6–7 <small>(11)</small> || Brach (5–2) || Andriese (3–5) || — || 15,963 || 66–67 || https://www.baseball-reference.com/boxes/BAL/BAL201509020.shtml |- bgcolor="ffcccc" | 134 || September 4 || @ Yankees || 2–5 || Severino (3–2) || Odorizzi (6–8) || Miller (30) || 32,530 || 66–68 || https://www.baseball-reference.com/boxes/NYA/NYA201509040.shtml |- bgcolor="ccffcc" | 135 || September 5 || @ Yankees || 3–2 || Cedeño (4–1) || Eovaldi (13–4) || Boxberger (34) || 35,030 || 67–68 || https://www.baseball-reference.com/boxes/NYA/NYA201509050.shtml |- bgcolor="ffcccc" | 136 || September 6 || @ Yankees || 4–6 || Nova (6–7) || Archer (12–11) || Miller (31) || 35,299 || 67–69 || https://www.baseball-reference.com/boxes/NYA/NYA201509060.shtml |- bgcolor="ffcccc" | 137 || September 7 || @ Tigers || 4–5 || Alburquerque (4–1) || Gomes (2–5) || Rondón (4) || 27,958 || 67–70 || https://www.baseball-reference.com/boxes/DET/DET201509070.shtml |- bgcolor="ffcccc" | 138 || September 8 || @ Tigers || 7–8 <small>(13)</small> || Ryan (2–3) || Bellatti (2–1) || — || 26,526 || 67–71 || https://www.baseball-reference.com/boxes/DET/DET201509080.shtml |- bgcolor="ccffcc" | 139 || September 9 || @ Tigers || 8–0 || Odorizzi (7–8) || Lobstein (3–7) || — || 25,932 || 68–71 || https://www.baseball-reference.com/boxes/DET/DET201509090.shtml |- bgcolor="ccffcc" | 140 || September 11 || Red Sox || 8–4 || Bellatti (3–1) || Tazawa (2–7) || — || 14,796 || 69–71 || https://www.baseball-reference.com/boxes/TBA/TBA201509110.shtml |- bgcolor="ffcccc" | 141 || September 12 || Red Sox || 4–10 || Porcello (8–12) || Moore (1–4) || — || 20,698 || 69–72 || https://www.baseball-reference.com/boxes/TBA/TBA201509120.shtml |- bgcolor="ffcccc" | 142 || September 13 || Red Sox || 0–2 || Hembree (1–0) || Romero (0–1) || Ross (2) || 15,402 || 69–73 || https://www.baseball-reference.com/boxes/TBA/TBA201509130.shtml |- bgcolor="ffcccc" | 143 || September 14 || Yankees || 1–4 || Cotham (1–0) || Boxberger (4–10) || Miller (33) || 11,940 || 69–74 || https://www.baseball-reference.com/boxes/TBA/TBA201509140.shtml |- bgcolor="ccffcc" | 144 || September 15 || Yankees || 6–3 || Odorizzi (8–8) || Rumbelow (1–1) || Gomes (1) || 13,539 || 70–74 || https://www.baseball-reference.com/boxes/TBA/TBA201509150.shtml |- bgcolor="ffcccc" | 145 || September 16 || Yankees || 1–3 || Severino (4–3) || Archer (12–12) || Miller (34) || 13,299 || 70–75 || https://www.baseball-reference.com/boxes/TBA/TBA201509160.shtml |- bgcolor="ffcccc" | 146 || September 17 || Orioles || 3–4 || Roe (4–2) || Colomé (6–5) || O'Day (3) || 9,617 || 70–76 || https://www.baseball-reference.com/boxes/TBA/TBA201509170.shtml |- bgcolor="ccffcc" | 147 || September 18 || Orioles || 8–6 || Smyly (3–2) || Wilson (2–2) || Boxberger (35) || 10,967 || 71–76 || https://www.baseball-reference.com/boxes/TBA/TBA201509180.shtml |- bgcolor="ffcccc" | 148 || September 19 || Orioles || 1–2 || Chen (10–7) || Ramírez (10–6) || Britton (34) || 17,053 || 71–77 || https://www.baseball-reference.com/boxes/TBA/TBA201509190.shtml |- bgcolor="ccffcc" | 149 || September 20 || Orioles || 7–6 || Yates (1–0) || Britton (4–1) || — || 17,801 || 72–77 || https://www.baseball-reference.com/boxes/TBA/TBA201509200.shtml |- bgcolor="ffcccc" | 150 || September 21 || @ Red Sox || 7–8 || Machi (2–0) || Gomes (2–6) || Ross (5) || 33,673 || 72–78 || https://www.baseball-reference.com/boxes/BOS/BOS201509210.shtml |- bgcolor="ccffcc" | 151 || September 22 || @ Red Sox || 5–2 || Moore (2–4) || Koehler (3–3) || Boxberger (36) || 33,673 || 73–78 || https://www.baseball-reference.com/boxes/BOS/BOS201509220.shtml |- bgcolor="ccffcc" | 152 || September 23 || @ Red Sox || 6–2 || Smyly (4–2) || Porcello (8–14) || Boxberger (37) || 32,753 || 74–78 || https://www.baseball-reference.com/boxes/BOS/BOS201509230.shtml |- bgcolor="ccffcc" | 153 || September 24 || @ Red Sox || 4–2 || Ramírez (11–6) || Miley (11–11) || Boxberger (38) || 34,916 || 75–78 || https://www.baseball-reference.com/boxes/BOS/BOS201509240.shtml |- bgcolor="ffcccc" | 154 || September 25 || @ Blue Jays || 3–5 || Dickey (11–11) || Odorizzi (8–9) || Osuna (18) || 47,696 || 75–79 || https://www.baseball-reference.com/boxes/TOR/TOR201509250.shtml |- bgcolor="ffcccc" | 155 || September 26 || @ Blue Jays || 8–10 || Price (18–5) || Archer (12–13) || Osuna (19) || 47,094 || 75–80 || https://www.baseball-reference.com/boxes/TOR/TOR201509260.shtml |- bgcolor="ffcccc" | 156 || September 27 || @ Blue Jays || 4–5 || Cecil (4–5) || Geltz (2–6) || — || 47,287 || 75–81 || https://www.baseball-reference.com/boxes/TOR/TOR201509270.shtml |- bgcolor="ccffcc" | 157 || September 29 || Marlins || 4–2 || Colomé (7–5) || Morris (5–4) || Boxberger (39) || 9,150 || 76–81 || https://www.baseball-reference.com/boxes/TBA/TBA201509290.shtml |- bgcolor="ccffcc" | 158 || September 30 || Marlins || 6–4 || Smyly (5–2) || Cosart (2–5) || Boxberger (40) || 9,431 || 77–81 || https://www.baseball-reference.com/boxes/TBA/TBA201509300.shtml |-

|- bgcolor="ccffcc" | 159 || October 1 || Marlins || 4–1 || Odorizzi (9–9) || Fernández (6–1) || Boxberger (41) || 9,657 || 78–81 || https://www.baseball-reference.com/boxes/TBA/TBA201510010.shtml |- bgcolor="ffcccc" | 160 || October 2 || Blue Jays || 4–8 || Buehrle (15–7) || Romero (0–2) || — || 13,668 || 78–82 || https://www.baseball-reference.com/boxes/TBA/TBA201510020.shtml |- bgcolor="ccffcc" | 161 || October 3 || Blue Jays || 4–3 || Colomé (8–5) || Osuna (1–6) || — || 21,963 || 79–82 || https://www.baseball-reference.com/boxes/TBA/TBA201510030.shtml |- bgcolor="ccffcc" | 162 || October 4 || Blue Jays || 12–3 || Moore (3–4) || Buehrle (15–8) || — || 15,815 || 80–82 || https://www.baseball-reference.com/boxes/TBA/TBA201510040.shtml |-