The 2015 Columbus Crew SC season was the club's 20th season of existence and their 20th consecutive season in Major League Soccer, the top flight of soccer in the United States and Canada. The first match of the season was on March 7 against Houston Dynamo. It was the second season under head coach Gregg Berhalter. The Crew's USL Pro affiliate this season was Austin Aztex.
In coach Berhalter's second season, he led the club to an MLS Cup appearance that resulted in a loss to the Portland Timbers. This season also saw returning striker Kei Kamara contend for the league's golden boot.
(on loan to Austin Aztex) (on loan to Austin Aztex)
The Crew started preseason in Columbus and played games in Texas and Florida before returning to Ohio.
Unsigned draft picks Sergio Campbell, Sagi Lev-Ari, Tomas Gomez and Kalen Ryden joined the team for preseason.
Under "Apps" for each section, the first number represents the number of starts, and the second number represents appearances as a substitute.
|- |colspan=12 align=center|Players who left Columbus during the season: |-
Draft picks are not automatically signed to the team roster. Only those who are signed to a contract will be listed as transfers in. The picks for the Columbus Crew are listed below: