The knock-out stage of the 2014 AFC Champions League was played from 6 May to 1 November 2014. A total of 16 teams competed in the knock-out stage.
The winners and runners-up of each of the eight groups in the group stage qualified for the knock-out stage. Both West Zone and East Zone had eight teams qualified.
In the knock-out stage, the 16 teams played a single-elimination tournament, with the teams split between the two zones until the final. Each tie was played on a home-and-away two-legged basis. The away goals rule, extra time (away goals do not apply in extra time) and penalty shoot-out were used to decide the winner if necessary.
The schedule of each round was as follows.
In the round of 16, the winners of one group played the runners-up of another group in the same zone, with the group winners hosting the second leg. The matchups were determined as follows:
The draw for the quarter-finals was held on 28 May 2014, 16:00 , at the AFC House in Kuala Lumpur, Malaysia. The "country protection" rule was not applied, so teams from the same association could be drawn into the same tie.
There was no draw for the semi-finals, with the matchups determined by the quarter-final draw: Winner QF1 vs. Winner QF2 (West Zone) and Winner QF3 vs. Winner QF4 (East Zone), with winners QF2 and QF4 hosting the second leg.
The draw to decide the order of two legs of the final was held after the quarter-final draw. <section begin=Bracket /> <section end=Bracket />
<section begin=Round of 16 />
|- |+West Zone
|+East Zone
<section end=Round of 16 />
Pohang Steelers won 3âÂÂ1 on aggregate.
Guangzhou Evergrande won 5âÂÂ2 on aggregate.
Al-Ain won 4âÂÂ2 on aggregate.
Al-Ittihad won 4âÂÂ1 on aggregate.
3âÂÂ3 on aggregate. Western Sydney Wanderers won on away goals.
4âÂÂ4 on aggregate. FC Seoul won on away goals.
2âÂÂ2 on aggregate. Al-Sadd won on away goals.
Al-Hilal won 4âÂÂ0 on aggregate.
<section begin=Quarter-finals />
|- |+West Zone
|+East Zone
<section end=Quarter-finals />
Al-Hilal won 1âÂÂ0 on aggregate.
Al-Ain won 5âÂÂ1 on aggregate.
0âÂÂ0 on aggregate. FC Seoul won 3âÂÂ0 on penalties.
2âÂÂ2 on aggregate. Western Sydney Wanderers won on away goals.
<section begin=Semi-finals />
|- |+West Zone
|+East Zone
<section end=Semi-finals />
Al-Hilal won 4âÂÂ2 on aggregate.
Western Sydney Wanderers won 2âÂÂ0 on aggregate.
<section begin=Final />
Western Sydney Wanderers won 1âÂÂ0 on aggregate.<section end=Final />