2013 Regional League Division 2 Southern Region is the 5th season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system.
No club was promoted to the Thai Division 1 League. Last years league champions Trang and runners up Pattani failed to qualify from the 2012 Regional League Division 2 championship pool.
Phattalung, Songkhla were relegated from the 2012 Thai Division 1 League.
Hat Yai, Songkhla have withdrawn from the 2013 campaign.
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